Structural Biologist (R5-R7)

Company: Eli Lilly and Company
Location: San Diego
Posted on: May 3, 2025

Job Description:

Eli Lilly and Company seeks a Structural Biologist (R5-R7) to support structure-based drug discovery (SBDD)projects focused on G protein-coupled receptors (GPCRs). Perform structure determination and drug design for GPCR and membrane protein targets as well as soluble protein targets. Apply biochemical, biophysical, and computational techniques to accelerate generation of high-quality reagents for X-ray crystallography and cryogenic electron microscopy (cryo-EM) studies. Determine structures and co-complex structures of protein targets for the design of small-molecule and antibody therapeutics. Develop integrative approaches to SBDD incorporating data and input from structural biology, biophysics, protein biochemistry, and medicinal chemistry teams. #LI-DNI

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Position requires a Ph.D. in Structural Biology, Biophysics, Biochemistry, Chemistry, or a related field, and 2 years of academic or employment experience with GPCR biology, pharmacology, and structure-based research studies of GPCRs. Academic or employment experience must include a minimum of: 2 years of experience with protein engineering, protein biochemistry, and protein structure determination by X-ray crystallography or cryo-EM; 2 years of experience with construct design, molecular cloning, and protein expression and purification; 2 years of experience with chromatographic methods for isolating recombinant proteins and HPLC/FPLC systems; 2 years of experience with SDS-PAGE, Western blot, thermal shift assays, and ELISA; and 2 years of experience with computational tools for protein structure determination and analysis, including CCP4, Phenix, COOT, PyMol, and Chimera. Part time telecommuting may be permitted. Up to 10% domestic and international travel required. #LI-DNI



Job location: San Diego, CA. RATE OF PAY: $168,709.00 - $178,709.00 per year. To apply, please visit https://jobsearch.lilly.com/ and enter job requisition number R-84158 when prompted. Alternatively, please send your resume, cover letter, and a copy of the ad to: Beth L. Berry, Lilly Corporate Center, Indianapolis, IN 46285.

Keywords: Eli Lilly and Company, La Mesa , Structural Biologist (R5-R7), Other , San Diego, California